G protein–coupled receptor kinase 5 regulates thrombin signaling in platelets via PAR-1

The interindividual variation in the functional response of platelets to activation by agonists is heritable. Genome-wide association studies (GWASs) of quantitative measures of platelet function have identified fewer than 20 distinctly associated variants, some with unknown mechanisms. Here, we rep...

Descripción completa

Detalles Bibliográficos
Autores principales: Downes, Kate, Zhao, Xuefei, Gleadall, Nicholas S., McKinney, Harriet, Kempster, Carly, Batista, Joana, Thomas, Patrick L., Cooper, Matthew, Michael, James V., Kreuzhuber, Roman, Wedderburn, Katherine, Waller, Kathryn, Varney, Bianca, Verdier, Hippolyte, Kriek, Neline, Ashford, Sofie E., Stirrups, Kathleen E., Dunster, Joanne L., McKenzie, Steven E., Ouwehand, Willem H., Gibbins, Jonathan M., Yang, Jing, Astle, William J., Ma, Peisong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Platelets and Thrombopoiesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9006276/
https://www.ncbi.nlm.nih.gov/pubmed/34581777
http://dx.doi.org/10.1182/bloodadvances.2021005453

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9006276/
https://www.ncbi.nlm.nih.gov/pubmed/34581777
http://dx.doi.org/10.1182/bloodadvances.2021005453

Ejemplares similares