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Neutrophil cathepsin G proteolysis of protease-activated receptor 4 generates a novel, functional tethered ligand
Platelet-neutrophil interactions regulate ischemic vascular injury. Platelets are activated by serine proteases that cleave protease-activated receptor (PAR) amino termini, resulting in an activating tethered ligand. Neutrophils release cathepsin G (CatG) at sites of injury and inflammation, which a...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society of Hematology
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9006282/ https://www.ncbi.nlm.nih.gov/pubmed/34883511 http://dx.doi.org/10.1182/bloodadvances.2021006133 |