Neutrophil cathepsin G proteolysis of protease-activated receptor 4 generates a novel, functional tethered ligand

Platelet-neutrophil interactions regulate ischemic vascular injury. Platelets are activated by serine proteases that cleave protease-activated receptor (PAR) amino termini, resulting in an activating tethered ligand. Neutrophils release cathepsin G (CatG) at sites of injury and inflammation, which a...

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Detalles Bibliográficos
Autores principales: Stoller, Michelle L., Basak, Indranil, Denorme, Frederik, Rowley, Jesse W., Alsobrooks, James, Parsawar, Krishna, Nieman, Marvin T., Yost, Christian Con, Hamilton, Justin R., Bray, Paul F., Campbell, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Stimulus Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9006282/
https://www.ncbi.nlm.nih.gov/pubmed/34883511
http://dx.doi.org/10.1182/bloodadvances.2021006133

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