Cryo-EM of NHEJ supercomplexes provides insights into DNA repair

Non-homologous end joining (NHEJ) is one of two critical mechanisms utilized in humans to repair DNA double-strand breaks (DSBs). Unrepaired or incorrect repair of DSBs can lead to apoptosis or cancer. NHEJ involves several proteins, including the Ku70/80 heterodimer, DNA-dependent protein kinase ca...

Descripción completa

Detalles Bibliográficos
Autores principales: Chaplin, Amanda K., Hardwick, Steven W., Kefala Stavridi, Antonia, Buehl, Christopher J., Goff, Noah J., Ropars, Virginie, Liang, Shikang, De Oliveira, Taiana Maia, Chirgadze, Dimitri Y., Meek, Katheryn, Charbonnier, Jean-Baptiste, Blundell, Tom L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9006396/
https://www.ncbi.nlm.nih.gov/pubmed/34352203
http://dx.doi.org/10.1016/j.molcel.2021.07.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9006396/
https://www.ncbi.nlm.nih.gov/pubmed/34352203
http://dx.doi.org/10.1016/j.molcel.2021.07.005

Ejemplares similares