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Chemical genetic activation of the cholinergic basal forebrain hippocampal circuit rescues memory loss in Alzheimer’s disease

BACKGROUND: The degeneration of the cholinergic circuit from the basal forebrain to the hippocampus contributes to memory loss in patients suffering from Alzheimer’s disease (AD). However, the internal relationships between the acetylcholine (Ach) cycle and memory decline during the early stages of...

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Detalles Bibliográficos
Autores principales: Liu, Weilin, Li, Jianhong, Yang, Minguang, Ke, Xiaohua, Dai, Yaling, Lin, Huawei, Wang, Sinuo, Chen, Lidian, Tao, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9006585/
https://www.ncbi.nlm.nih.gov/pubmed/35418161
http://dx.doi.org/10.1186/s13195-022-00994-w