The smoothened agonist SAG reduces mitochondrial dysfunction and neurotoxicity of frataxin-deficient astrocytes

BACKGROUND: Friedreich’s ataxia is a rare hereditary neurodegenerative disease caused by decreased levels of the mitochondrial protein frataxin. Similar to other neurodegenerative pathologies, previous studies suggested that astrocytes might contribute to the progression of the disease. To fully und...

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Detalles Bibliográficos
Autores principales: Vicente-Acosta, Andrés, Giménez-Cassina, Alfredo, Díaz-Nido, Javier, Loria, Frida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9006607/
https://www.ncbi.nlm.nih.gov/pubmed/35413853
http://dx.doi.org/10.1186/s12974-022-02442-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9006607/
https://www.ncbi.nlm.nih.gov/pubmed/35413853
http://dx.doi.org/10.1186/s12974-022-02442-w

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