Mutagenesis of bracelet cyclotide hyen D reveals functionally and structurally critical residues for membrane binding and cytotoxicity

Cyclotides have a wide range of bioactivities relevant for agricultural and pharmaceutical applications. This large family of naturally occurring macrocyclic peptides is divided into three subfamilies, with the bracelet subfamily being the largest and comprising the most potent cyclotides reported t...

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Detalles Bibliográficos
Autores principales: Du, Qingdan, Huang, Yen-Hua, Wang, Conan K., Kaas, Quentin, Craik, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9006653/
https://www.ncbi.nlm.nih.gov/pubmed/35283188
http://dx.doi.org/10.1016/j.jbc.2022.101822

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9006653/
https://www.ncbi.nlm.nih.gov/pubmed/35283188
http://dx.doi.org/10.1016/j.jbc.2022.101822

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