An antibody Fc engineered for conditional antibody-dependent cellular cytotoxicity at the low tumor microenvironment pH

Despite the exquisite specificity and high affinity of antibody-based cancer therapies, treatment side effects can occur since the tumor-associated antigens targeted are also present on healthy cells. However, the low pH of the tumor microenvironment provides an opportunity to develop conditionally...

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Detalles Bibliográficos
Autores principales: Liu, Yutong, Lee, Alison G., Nguyen, Annalee W., Maynard, Jennifer A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9006656/
https://www.ncbi.nlm.nih.gov/pubmed/35248534
http://dx.doi.org/10.1016/j.jbc.2022.101798

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9006656/
https://www.ncbi.nlm.nih.gov/pubmed/35248534
http://dx.doi.org/10.1016/j.jbc.2022.101798

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