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An antibody Fc engineered for conditional antibody-dependent cellular cytotoxicity at the low tumor microenvironment pH
Despite the exquisite specificity and high affinity of antibody-based cancer therapies, treatment side effects can occur since the tumor-associated antigens targeted are also present on healthy cells. However, the low pH of the tumor microenvironment provides an opportunity to develop conditionally...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9006656/ https://www.ncbi.nlm.nih.gov/pubmed/35248534 http://dx.doi.org/10.1016/j.jbc.2022.101798 |