Enhanced Cross-Reactive and Polyfunctional Effector-Memory T Cell Responses by ICVAX—a Human PD1-Based Bivalent HIV-1 Gag-p41 Mosaic DNA Vaccine

Vaccine-induced protective T cell immunity is necessary for HIV-1 functional cure. We previously reported that rhesus PD1-Gag-based DNA vaccination sustained simian-human immunodeficiency virus (SHIV) suppression by inducing effector-memory CD8(+) T cells. Here, we investigated a human PD1-Gag-based...

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Detalles Bibliográficos
Autores principales: Chen, Samantha M. Y., Wong, Yik Chun, Yim, Lok Yan, Zhang, Haoji, Wang, Hui, Lui, Grace Chung Yan, Li, Xin, Tang, Xian, Cheng, Lin, Du, Yanhua, Peng, Qiaoli, Wang, Jinlin, Kwok, Hau-yee, Huang, Haode, Lau, Thomas Tsz-Kan, Chan, Denise Pui Chung, Wong, Bonnie Chun Kwan, Liu, Li, Chakrabarti, Lisa A., Lee, Shui Shan, Chen, Zhiwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Vaccines and Antiviral Agents
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9006887/
https://www.ncbi.nlm.nih.gov/pubmed/35297660
http://dx.doi.org/10.1128/jvi.02161-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9006887/
https://www.ncbi.nlm.nih.gov/pubmed/35297660
http://dx.doi.org/10.1128/jvi.02161-21

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