Water enables diastereodivergency in bispidine-based chiral amine-catalyzed asymmetric Mannich reaction of cyclic N-sulfonyl ketimines with ketones

Tuning diastereoselectivity is a great challenge in asymmetric catalysis for the inherent stereochemical bias of the substrates. Here, we report a diastereodivergent asymmetric Mannich reaction of cyclic N-sulfonyl ketimines with ketones catalyzed by a bispidine-based chiral amine catalyst, in which...

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Detalles Bibliográficos
Autores principales: Li, Gonglin, Zhang, Yan, Zeng, Hongkun, Feng, Xiaoming, Su, Zhishan, Lin, Lili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9006921/
https://www.ncbi.nlm.nih.gov/pubmed/35509468
http://dx.doi.org/10.1039/d2sc00446a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9006921/
https://www.ncbi.nlm.nih.gov/pubmed/35509468
http://dx.doi.org/10.1039/d2sc00446a

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