Aurintricarboxylic acid is a canonical disruptor of the TAZ-TEAD transcriptional complex

Disrupting the formation of the oncogenic YAP/TAZ-TEAD transcriptional complex holds substantial therapeutic potential. However, the three protein interaction interfaces of this complex cannot be easily disrupted using small molecules. Here, we report that the pharmacologically active small molecule...

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Detalles Bibliográficos
Autores principales: Che, Kepeng, Pobbati, Ajaybabu V., Seavey, Caleb N., Fedorov, Yuriy, Komar, Anton A., Burtscher, Ashley, Ma, Shuang, Rubin, Brian P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9007350/
https://www.ncbi.nlm.nih.gov/pubmed/35417479
http://dx.doi.org/10.1371/journal.pone.0266143

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9007350/
https://www.ncbi.nlm.nih.gov/pubmed/35417479
http://dx.doi.org/10.1371/journal.pone.0266143

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