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An efficient and robust approach to Mendelian randomization with measured pleiotropic effects in a high-dimensional setting
Valid estimation of a causal effect using instrumental variables requires that all of the instruments are independent of the outcome conditional on the risk factor of interest and any confounders. In Mendelian randomization studies with large numbers of genetic variants used as instruments, it is un...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9007434/ https://www.ncbi.nlm.nih.gov/pubmed/33155035 http://dx.doi.org/10.1093/biostatistics/kxaa045 |