A developmentally programmed splicing failure contributes to DNA damage response attenuation during mammalian zygotic genome activation

Transition from maternal to embryonic transcriptional control is crucial for embryogenesis. However, alternative splicing regulation during this process remains understudied. Using transcriptomic data from human, mouse, and cow preimplantation development, we show that the stage of zygotic genome ac...

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Detalles Bibliográficos
Autores principales: Wyatt, Christopher D. R., Pernaute, Barbara, Gohr, André, Miret-Cuesta, Marta, Goyeneche, Lucia, Rovira, Quirze, Salzer, Marion C., Boke, Elvan, Bogdanovic, Ozren, Bonnal, Sophie, Irimia, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9007516/
https://www.ncbi.nlm.nih.gov/pubmed/35417229
http://dx.doi.org/10.1126/sciadv.abn4935

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9007516/
https://www.ncbi.nlm.nih.gov/pubmed/35417229
http://dx.doi.org/10.1126/sciadv.abn4935

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