Protection of nascent DNA at stalled replication forks is mediated by phosphorylation of RIF1 intrinsically disordered region

RIF1 is a multifunctional protein that plays key roles in the regulation of DNA processing. During repair of DNA double-strand breaks (DSBs), RIF1 functions in the 53BP1-Shieldin pathway that inhibits resection of DNA ends to modulate the cellular decision on which repair pathway to engage. Under co...

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Detalles Bibliográficos
Autores principales: Balasubramanian, Sandhya, Andreani, Matteo, Andrade, Júlia Goncalves, Saha, Tannishtha, Sundaravinayagam, Devakumar, Garzón, Javier, Zhang, Wenzhu, Popp, Oliver, Hiraga, Shin-ichiro, Rahjouei, Ali, Rosen, Daniel B, Mertins, Philipp, Chait, Brian T, Donaldson, Anne D, Di Virgilio, Michela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9007588/
https://www.ncbi.nlm.nih.gov/pubmed/35416772
http://dx.doi.org/10.7554/eLife.75047

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9007588/
https://www.ncbi.nlm.nih.gov/pubmed/35416772
http://dx.doi.org/10.7554/eLife.75047

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