Efficient simulation of clinical target response surfaces

Simulation of combination therapies is challenging due to computational complexity. Either a simple model is used to simulate the response for many combinations of concentration to generate a response surface but parameter variability and uncertainty are neglected and the concentrations are constant...

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Detalles Bibliográficos
Autores principales: Lill, Daniel, Kümmel, Anne, Mitov, Venelin, Kaschek, Daniel, Gobeau, Nathalie, Schmidt, Henning, Timmer, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9007598/
https://www.ncbi.nlm.nih.gov/pubmed/35199969
http://dx.doi.org/10.1002/psp4.12779

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9007598/
https://www.ncbi.nlm.nih.gov/pubmed/35199969
http://dx.doi.org/10.1002/psp4.12779

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