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Mechanistic modeling of a human IgG(4) monoclonal antibody (tralokinumab) Fab‐arm exchange with endogenous IgG(4) in healthy volunteers
Therapeutic IgG(4) antibodies engage in Fab‐arm exchange with endogenous human immunoglobulin G4 (IgG(4)) to form monovalent hybrid molecules. A mechanistic population model was developed to quantitatively characterize the dynamic Fab‐arm exchange of tralokinumab, a human IgG(4) monoclonal antibody...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9007600/ https://www.ncbi.nlm.nih.gov/pubmed/35023315 http://dx.doi.org/10.1002/psp4.12738 |