Nuclear translocation of p85β promotes tumorigenesis of PIK3CA helical domain mutant cancer

PI3Ks consist of p110 catalytic subunits and p85 regulatory subunits. PIK3CA, encoding p110α, is frequently mutated in human cancers. Most PIK3CA mutations are clustered in the helical domain or the kinase domain. Here, we report that p85β disassociates from p110α helical domain mutant protein and t...

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Detalles Bibliográficos
Autores principales: Hao, Yujun, He, Baoyu, Wu, Liping, Li, Yamu, Wang, Chao, Wang, Ting, Sun, Longci, Zhang, Yanhua, Zhan, Yangyang, Zhao, Yiqing, Markowitz, Sanford, Veigl, Martina, Conlon, Ronald A., Wang, Zhenghe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9007954/
https://www.ncbi.nlm.nih.gov/pubmed/35418124
http://dx.doi.org/10.1038/s41467-022-29585-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9007954/
https://www.ncbi.nlm.nih.gov/pubmed/35418124
http://dx.doi.org/10.1038/s41467-022-29585-x

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