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CHD7 regulates bone-fat balance by suppressing PPAR-γ signaling

Chromodomain helicase DNA-binding protein 7 (CHD7), an ATP-dependent eukaryotic chromatin remodeling enzyme, is essential for the development of organs. The mutation of CHD7 is the main cause of CHARGE syndrome, but its function and mechanism in skeletal system remain unclear. Here, we show conditio...

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Detalles Bibliográficos
Autores principales: Liu, Caojie, Xiong, Qiuchan, Li, Qiwen, Lin, Weimin, Jiang, Shuang, Zhang, Danting, Wang, Yuan, Duan, Xiaobo, Gong, Ping, Kang, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9007978/
https://www.ncbi.nlm.nih.gov/pubmed/35418650
http://dx.doi.org/10.1038/s41467-022-29633-6