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TGF-β induces GBM mesenchymal transition through upregulation of CLDN4 and nuclear translocation to activate TNF-α/NF-κB signal pathway
Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor. The unregulated expression of Claudin-4 (CLDN4) plays an important role in tumor progression. However, the biological role of CLDN4 in GBM is still unknown. This study aimed to determine whether CLDN4 mediates glioma...
Autores principales: | Yan, Tengfeng, Tan, Yinqiu, Deng, Gang, Sun, Zhiqiang, Liu, Baohui, Wang, Yixuan, Yuan, Fanen, Sun, Qian, Hu, Ping, Gao, Lun, Tian, Daofeng, Chen, Qianxue |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008023/ https://www.ncbi.nlm.nih.gov/pubmed/35418179 http://dx.doi.org/10.1038/s41419-022-04788-8 |
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