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The lipophilic cyclic peptide cyclosporin A induces aggregation of gel-forming mucins

Cyclic peptides are good candidates for orally delivered therapeutics, however, issues remain in their development due to low intestinal permeability. Although some of the biological factors have been reported that regulate intestinal permeation of cyclic peptides, the influence of the mucus barrier...

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Detalles Bibliográficos
Autores principales: Kishimoto, Hisanao, Ridley, Caroline, Thornton, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008041/
https://www.ncbi.nlm.nih.gov/pubmed/35418571
http://dx.doi.org/10.1038/s41598-022-10125-y