Presenilin 2 N141I mutation induces hyperactive immune response through the epigenetic repression of REV-ERBα

Hyperimmunity drives the development of Alzheimer disease (AD). The immune system is under the circadian control, and circadian abnormalities aggravate AD progress. Here, we investigate how an AD-linked mutation deregulates expression of circadian genes and induces cognitive decline using the knock-...

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Detalles Bibliográficos
Autores principales: Nam, Hyeri, Lee, Younghwan, Kim, Boil, Lee, Ji-Won, Hwang, Seohyeon, An, Hyun-Kyu, Chung, Kyung Min, Park, Youngjin, Hong, Jihyun, Kim, Kyungjin, Kim, Eun-Kyoung, Choe, Han Kyoung, Yu, Seong-Woon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008044/
https://www.ncbi.nlm.nih.gov/pubmed/35418126
http://dx.doi.org/10.1038/s41467-022-29653-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008044/
https://www.ncbi.nlm.nih.gov/pubmed/35418126
http://dx.doi.org/10.1038/s41467-022-29653-2

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