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Homology-based repair induced by CRISPR-Cas nucleases in mammalian embryo genome editing
Recent advances in genome editing, especially CRISPR-Cas nucleases, have revolutionized both laboratory research and clinical therapeutics. CRISPR-Cas nucleases, together with the DNA damage repair pathway in cells, enable both genetic diversification by classical non-homologous end joining (c-NHEJ)...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Higher Education Press
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008090/ https://www.ncbi.nlm.nih.gov/pubmed/33945139 http://dx.doi.org/10.1007/s13238-021-00838-7 |