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Algorithmic multiscale analysis for the FcRn mediated regulation of antibody PK in human

A demonstration is provided on how algorithmic asymptotic analysis of multi-scale pharmacokinetics (PK) systems can provide (1) system level understanding and (2) predictions on the response of the model when parameters vary. Being algorithmic, this type of analysis is not hindered by the size or co...

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Detalles Bibliográficos
Autores principales: Patsatzis, Dimitris G., Wu, Shengjia, Shah, Dhaval K., Goussis, Dimitris A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008124/
https://www.ncbi.nlm.nih.gov/pubmed/35418134
http://dx.doi.org/10.1038/s41598-022-09846-x