A Bionic‐Homodimerization Strategy for Optimizing Modulators of Protein–Protein Interactions: From Statistical Mechanics Theory to Potential Clinical Translation

Emerging protein–protein interaction (PPI) modulators have brought out exciting ability as therapeutics in human diseases, but its clinical translation has been greatly hampered by the limited affinity. Inspired by the homodimerize structure of antibody, the homodimerization contributes hugely to ge...

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Detalles Bibliográficos
Autores principales: Yan, Jin, Zheng, Xiaoqiang, You, Weiming, He, Wangxiao, Xu, Guang‐Kui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008432/
https://www.ncbi.nlm.nih.gov/pubmed/35166067
http://dx.doi.org/10.1002/advs.202105179

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008432/
https://www.ncbi.nlm.nih.gov/pubmed/35166067
http://dx.doi.org/10.1002/advs.202105179

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