Benefits of a Skull‐Interfaced Flexible and Implantable Multilight Emitting Diode Array for Photobiomodulation in Ischemic Stroke

Photobiomodulation (PBM) has received attention due to its potential for improving tissue function and enhancing regeneration in stroke. A lightweight, compact, and simple system of miniaturized electronic devices consisting of packaged light‐emitting diodes (LEDs) that incorporates a flexible subst...

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Autores principales: Kim, Hyunha, Kim, Min Jae, Kwon, Young Woo, Jeon, Sangheon, Lee, Seo‐Yeon, Kim, Chang‐Seok, Choi, Byung Tae, Shin, Yong‐Il, Hong, Suck Won, Shin, Hwa Kyoung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008794/
https://www.ncbi.nlm.nih.gov/pubmed/35076161
http://dx.doi.org/10.1002/advs.202104629
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author Kim, Hyunha
Kim, Min Jae
Kwon, Young Woo
Jeon, Sangheon
Lee, Seo‐Yeon
Kim, Chang‐Seok
Choi, Byung Tae
Shin, Yong‐Il
Hong, Suck Won
Shin, Hwa Kyoung
author_facet Kim, Hyunha
Kim, Min Jae
Kwon, Young Woo
Jeon, Sangheon
Lee, Seo‐Yeon
Kim, Chang‐Seok
Choi, Byung Tae
Shin, Yong‐Il
Hong, Suck Won
Shin, Hwa Kyoung
author_sort Kim, Hyunha
collection PubMed
description Photobiomodulation (PBM) has received attention due to its potential for improving tissue function and enhancing regeneration in stroke. A lightweight, compact, and simple system of miniaturized electronic devices consisting of packaged light‐emitting diodes (LEDs) that incorporates a flexible substrate for in vivo brain PBM in a mouse model is developed. Using this device platform, the preventive and therapeutic effects of PBM affixed to the exposed skull of mice in the photothrombosis and middle cerebral artery occlusion stroke model are evaluated. Among the wavelength range of 630, 850, and 940 nm LED array, the PBM with 630‐nm LED array is proved to be the most effective for reducing the infarction volume and neurological impairment after ischemic stroke. Moreover, the PBM with 630 nm LED array remarkably improves the capability of spatial learning and memory in the chronic poststroke phase, attenuates AIM2 inflammasome activation and inflammasome‐mediated pyroptosis, and modulates microglial polarization in the hippocampus and cortex 7 days following ischemic stroke. Thus, PBM may prevent tissue and functional damage in acute ischemic injury, thereby attenuating the development of cognitive impairment after stroke.
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spelling pubmed-90087942022-04-15 Benefits of a Skull‐Interfaced Flexible and Implantable Multilight Emitting Diode Array for Photobiomodulation in Ischemic Stroke Kim, Hyunha Kim, Min Jae Kwon, Young Woo Jeon, Sangheon Lee, Seo‐Yeon Kim, Chang‐Seok Choi, Byung Tae Shin, Yong‐Il Hong, Suck Won Shin, Hwa Kyoung Adv Sci (Weinh) Research Articles Photobiomodulation (PBM) has received attention due to its potential for improving tissue function and enhancing regeneration in stroke. A lightweight, compact, and simple system of miniaturized electronic devices consisting of packaged light‐emitting diodes (LEDs) that incorporates a flexible substrate for in vivo brain PBM in a mouse model is developed. Using this device platform, the preventive and therapeutic effects of PBM affixed to the exposed skull of mice in the photothrombosis and middle cerebral artery occlusion stroke model are evaluated. Among the wavelength range of 630, 850, and 940 nm LED array, the PBM with 630‐nm LED array is proved to be the most effective for reducing the infarction volume and neurological impairment after ischemic stroke. Moreover, the PBM with 630 nm LED array remarkably improves the capability of spatial learning and memory in the chronic poststroke phase, attenuates AIM2 inflammasome activation and inflammasome‐mediated pyroptosis, and modulates microglial polarization in the hippocampus and cortex 7 days following ischemic stroke. Thus, PBM may prevent tissue and functional damage in acute ischemic injury, thereby attenuating the development of cognitive impairment after stroke. John Wiley and Sons Inc. 2022-01-25 /pmc/articles/PMC9008794/ /pubmed/35076161 http://dx.doi.org/10.1002/advs.202104629 Text en © 2022 The Authors. Advanced Science published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Kim, Hyunha
Kim, Min Jae
Kwon, Young Woo
Jeon, Sangheon
Lee, Seo‐Yeon
Kim, Chang‐Seok
Choi, Byung Tae
Shin, Yong‐Il
Hong, Suck Won
Shin, Hwa Kyoung
Benefits of a Skull‐Interfaced Flexible and Implantable Multilight Emitting Diode Array for Photobiomodulation in Ischemic Stroke
title Benefits of a Skull‐Interfaced Flexible and Implantable Multilight Emitting Diode Array for Photobiomodulation in Ischemic Stroke
title_full Benefits of a Skull‐Interfaced Flexible and Implantable Multilight Emitting Diode Array for Photobiomodulation in Ischemic Stroke
title_fullStr Benefits of a Skull‐Interfaced Flexible and Implantable Multilight Emitting Diode Array for Photobiomodulation in Ischemic Stroke
title_full_unstemmed Benefits of a Skull‐Interfaced Flexible and Implantable Multilight Emitting Diode Array for Photobiomodulation in Ischemic Stroke
title_short Benefits of a Skull‐Interfaced Flexible and Implantable Multilight Emitting Diode Array for Photobiomodulation in Ischemic Stroke
title_sort benefits of a skull‐interfaced flexible and implantable multilight emitting diode array for photobiomodulation in ischemic stroke
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008794/
https://www.ncbi.nlm.nih.gov/pubmed/35076161
http://dx.doi.org/10.1002/advs.202104629
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