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Temporal and brain region‐specific elevations of soluble Amyloid‐β(40‐42) in the Ts65Dn mouse model of Down syndrome and Alzheimer’s disease
Down syndrome (DS) is a leading cause of intellectual disability that also results in hallmark Alzheimer's disease (AD) pathologies such as amyloid beta (Aβ) plaques and hyperphosphorylated tau. The Ts65Dn mouse model is commonly used to study DS, as trisomic Ts65Dn mice carry 2/3 of the tripli...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9009111/ https://www.ncbi.nlm.nih.gov/pubmed/35290711 http://dx.doi.org/10.1111/acel.13590 |