PIAS1-mediated SUMOylation of influenza A virus PB2 restricts viral replication and virulence

Host defense systems employ posttranslational modifications to protect against invading pathogens. Here, we found that protein inhibitor of activated STAT 1 (PIAS1) interacts with the nucleoprotein (NP), polymerase basic protein 1 (PB1), and polymerase basic protein 2 (PB2) of influenza A virus (IAV...

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Detalles Bibliográficos
Autores principales: Wang, Guangwen, Zhao, Yuhui, Zhou, Yuan, Jiang, Li, Liang, Libin, Kong, Fandi, Yan, Ya, Wang, Xuyuan, Wang, Yihan, Wen, Xia, Zeng, Xianying, Tian, Guobin, Deng, Guohua, Shi, Jianzhong, Liu, Liling, Chen, Hualan, Li, Chengjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9009768/
https://www.ncbi.nlm.nih.gov/pubmed/35377920
http://dx.doi.org/10.1371/journal.ppat.1010446

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9009768/
https://www.ncbi.nlm.nih.gov/pubmed/35377920
http://dx.doi.org/10.1371/journal.ppat.1010446

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