Effect of cenobamate on the single‐dose pharmacokinetics of multiple cytochrome P450 probes using a cocktail approach in healthy subjects

This study was designed to evaluate the effects of cenobamate, an antiseizure medication for focal seizures, on the pharmacokinetics of cytochrome P450 probes (bupropion, CYP2B6; midazolam, CYP3A4/5; warfarin, CYP2C9; and omeprazole, CYP2C19) in healthy subjects. Probes were administered alone on da...

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Detalles Bibliográficos
Autores principales: Greene, Stephen A., Kwak, Charles, Kamin, Marc, Vernillet, Laurent, Glenn, Kelli J., Gabriel, Lana, Kim, Hong Wook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010261/
https://www.ncbi.nlm.nih.gov/pubmed/34877801
http://dx.doi.org/10.1111/cts.13204

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010261/
https://www.ncbi.nlm.nih.gov/pubmed/34877801
http://dx.doi.org/10.1111/cts.13204

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