Cargando…

Effect of cenobamate on the single‐dose pharmacokinetics of multiple cytochrome P450 probes using a cocktail approach in healthy subjects

This study was designed to evaluate the effects of cenobamate, an antiseizure medication for focal seizures, on the pharmacokinetics of cytochrome P450 probes (bupropion, CYP2B6; midazolam, CYP3A4/5; warfarin, CYP2C9; and omeprazole, CYP2C19) in healthy subjects. Probes were administered alone on da...

Descripción completa

Detalles Bibliográficos
Autores principales:	Greene, Stephen A., Kwak, Charles, Kamin, Marc, Vernillet, Laurent, Glenn, Kelli J., Gabriel, Lana, Kim, Hong Wook
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010261/ https://www.ncbi.nlm.nih.gov/pubmed/34877801 http://dx.doi.org/10.1111/cts.13204

Ejemplares similares

Effects of Upadacitinib Coadministration on the Pharmacokinetics of Sensitive Cytochrome P450 Probe Substrates: A Study With the Modified Cooperstown 5+1 Cocktail
por: Mohamed, Mohamed‐Eslam F., et al.
Publicado: (2019)

Effects of a Fixed-Dose Co-Formulation of Daclatasvir, Asunaprevir, and Beclabuvir on the Pharmacokinetics of a Cocktail of Cytochrome P450 and Drug Transporter Substrates in Healthy Subjects
por: Garimella, Tushar, et al.
Publicado: (2017)

The Development and Validation of a Novel “Dual Cocktail” Probe for Cytochrome P450s and Transporter Functions to Evaluate Pharmacokinetic Drug-Drug and Herb-Drug Interactions
por: Kwon, Mihwa, et al.
Publicado: (2020)

Anticonvulsant effects of cenobamate in chemically and electrically induced seizure models in rodents
por: Melnick, Susan M., et al.
Publicado: (2023)

Effects of cytochrome P450 oxidoreductase genotypes on the pharmacokinetics of amlodipine in healthy Korean subjects
por: Han, Ji Min, et al.
Publicado: (2020)

Effect of fermented red ginseng on cytochrome P450 and P‐glycoprotein activity in healthy subjects, as evaluated using the cocktail approach
por: Kim, Min‐Gul, et al.
Publicado: (2016)

Impact of Acute Inflammation on Cytochromes P450 Activity Assessed by the Geneva Cocktail
por: Lenoir, Camille, et al.
Publicado: (2021)

Evaluation of the effects of four types of tea on the activity of cytochrome P450 enzymes with a probe cocktail and HPLC-MS/MS
por: Wang, Xueyan, et al.
Publicado: (2022)

Safety of the Geneva Cocktail, a Cytochrome P450 and P-Glycoprotein Phenotyping Cocktail, in Healthy Volunteers from Three Different Geographic Origins
por: Rollason, Victoria, et al.
Publicado: (2020)

Probing the Role of the Hinge Segment of Cytochrome P450 Oxidoreductase in the Interaction with Cytochrome P450
por: Campelo, Diana, et al.
Publicado: (2018)

The Effect of Vinpocetine on Human Cytochrome P450 Isoenzymes by Using a Cocktail Method
por: Kong, Lingti, et al.
Publicado: (2016)

Influences of Anlotinib on Cytochrome P450 Enzymes in Rats Using a Cocktail Method
por: Sun, Wei, et al.
Publicado: (2017)

Evaluation of lentinan effects on cytochrome P450 activity in rats by a cocktail method
por: Lin, Yiping, et al.
Publicado: (2019)

Screening of the whole human cytochrome P450 complement (CYPome) with enzyme bag cocktails
por: Sharma, Sangeeta Shrestha, et al.
Publicado: (2020)

Drug-drug interaction of acetaminophen and roxithromycin with the cocktail of cytochrome P450 and hepatotoxicity in rats
por: Liu, Xiang, et al.
Publicado: (2020)

Effect of nivasorexant (ACT‐539313), a selective orexin‐1‐receptor antagonist, on multiple cytochrome P450 probe substrates in vitro and in vivo using a cocktail approach in healthy subjects
por: Berger, Benjamin, et al.
Publicado: (2023)

Use of a cocktail probe to assess potential drug interactions with cytochrome P450 after administration of belatacept, a costimulatory immunomodulator
por: Williams, Daphne, et al.
Publicado: (2016)

Effect of Naoxintong Capsules on the Activities of CYP450 and Metabolism of Metoprolol Tartrate in Rats Evaluated by Probe Cocktail and Pharmacokinetic Methods
por: Ouyang, Huizi, et al.
Publicado: (2019)

Pharmacokinetic drug interactions of asciminib with the sensitive cytochrome P450 probe substrates midazolam, warfarin, and repaglinide in healthy participants
por: Hoch, Matthias, et al.
Publicado: (2022)

Evaluation of the impact of vindoline, an active components of Catharanthus roseus, on rat hepatic cytochrome P450 enzymes by using a cocktail of probe drugs
por: Zhang, Yuqian, et al.
Publicado: (2023)

Pharmacokinetics and safety of cenobamate, a novel antiseizure medication, in healthy Japanese, and an ethnic comparison with healthy non‐Japanese
por: Yang, Eunsol, et al.
Publicado: (2021)

1-Aminobenzotriazole: A Mechanism-Based Cytochrome P450 Inhibitor and Probe of Cytochrome P450 Biology
por: de Montellano, Paul R Ortiz
Publicado: (2018)

Geneva Cocktail for Cytochrome P450 and P-Glycoprotein Activity Assessment Using Dried Blood Spots
por: Bosilkovska, M, et al.
Publicado: (2014)

An in-vitro cocktail assay for assessing compound-mediated inhibition of six major cytochrome P450 enzymes
por: Wang, Jing-Jing, et al.
Publicado: (2014)

Inhibition and Induction by Poziotinib of Different Rat Cytochrome P450 Enzymes In Vivo and in an In Vitro Cocktail Method
por: Wang, Jinhui, et al.
Publicado: (2021)

Pharmacokinetic Interactions of Herbs with Cytochrome P450 and P-Glycoprotein
por: Cho, Hyun-Jong, et al.
Publicado: (2015)

Pharmacokinetics, toxicity, and cytochrome P450 modulatory activity of plumbagin
por: Sumsakul, Wiriyaporn, et al.
Publicado: (2016)

Pharmacokinetic Effects of Isavuconazole Coadministration With the Cytochrome P450 Enzyme Substrates Bupropion, Repaglinide, Caffeine, Dextromethorphan, and Methadone in Healthy Subjects
por: Yamazaki, Takao, et al.
Publicado: (2016)

Randomized phase 2 study of adjunctive cenobamate in patients with uncontrolled focal seizures
por: Chung, Steve S., et al.
Publicado: (2020)

Application of a cocktail approach to screen cytochrome P450 BM3 libraries for metabolic activity and diversity
por: Reinen, Jelle, et al.
Publicado: (2016)

Effects of Cytochrome P450 Inhibition and Induction on the Phenotyping Metrics of the Basel Cocktail: A Randomized Crossover Study
por: Derungs, Adrian, et al.
Publicado: (2015)

Evaluation of the inhibition potential of plumbagin against cytochrome P450 using LC-MS/MS and cocktail approach
por: Chen, Ang, et al.
Publicado: (2016)

Effect of Short-Term Fasting on Systemic Cytochrome P450-Mediated Drug Metabolism in Healthy Subjects: A Randomized, Controlled, Crossover Study Using a Cocktail Approach
por: Lammers, Laureen A., et al.
Publicado: (2017)

Characterization of the Effect of Upadacitinib on the Pharmacokinetics of Bupropion, a Sensitive Cytochrome P450 2B6 Probe Substrate
por: Mohamed, Mohamed‐Eslam F., et al.
Publicado: (2020)

Drug Interaction Potential of Osilodrostat (LCI699) Based on Its Effect on the Pharmacokinetics of Probe Drugs of Cytochrome P450 Enzymes in Healthy Adults
por: Armani, Sara, et al.
Publicado: (2017)

Is Cenobamate the Breakthrough We Have Been Wishing for?
por: Specchio, Nicola, et al.
Publicado: (2021)

Impact of SARS‐CoV‐2 Infection (COVID‐19) on Cytochromes P450 Activity Assessed by the Geneva Cocktail
por: Lenoir, Camille, et al.
Publicado: (2021)

Inhibitory Mechanisms of Lekethromycin in Dog Liver Cytochrome P450 Enzymes Based on UPLC-MS/MS Cocktail Method
por: Sun, Pan, et al.
Publicado: (2023)

Effect of Ginkgo biloba special extract EGb 761® on human cytochrome P450 activity: a cocktail interaction study in healthy volunteers
por: Zadoyan, G., et al.
Publicado: (2011)

Short-Term Fasting Alters Pharmacokinetics of Cytochrome P450 Probe Drugs: Does Protein Binding Play a Role?
por: Lammers, Laureen A., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_eecppinvlucfcvbk7pc6h7eqgh