A case study of a patient‐centered reverse translational systems‐based approach to understand adverse event profiles in drug development

Adverse drug reactions (ADRs) of targeted therapy drugs (TTDs) are frequently unexpected and long‐term toxicities detract from exceptional efficacy of new TTDs. In this proof‐of‐concept study, we explored how molecular causation involved in trastuzumab‐induced cardiotoxicity changes when trastuzumab...

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Detalles Bibliográficos
Autores principales: Kim, Sarah, Lahu, Gezim, Vakilynejad, Majid, Soldatos, Theodoros G., Jackson, David B., Lesko, Lawrence J., Trame, Mirjam N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010262/
https://www.ncbi.nlm.nih.gov/pubmed/35014203
http://dx.doi.org/10.1111/cts.13219

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010262/
https://www.ncbi.nlm.nih.gov/pubmed/35014203
http://dx.doi.org/10.1111/cts.13219

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