Cargando…

A case study of a patient‐centered reverse translational systems‐based approach to understand adverse event profiles in drug development

Adverse drug reactions (ADRs) of targeted therapy drugs (TTDs) are frequently unexpected and long‐term toxicities detract from exceptional efficacy of new TTDs. In this proof‐of‐concept study, we explored how molecular causation involved in trastuzumab‐induced cardiotoxicity changes when trastuzumab...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Sarah, Lahu, Gezim, Vakilynejad, Majid, Soldatos, Theodoros G., Jackson, David B., Lesko, Lawrence J., Trame, Mirjam N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010262/ https://www.ncbi.nlm.nih.gov/pubmed/35014203 http://dx.doi.org/10.1111/cts.13219

Ejemplares similares

Application of a patient‐centered reverse translational systems‐based approach to understand mechanisms of an adverse drug reaction of immune checkpoint inhibitors
por: Kim, Sarah, et al.
Publicado: (2022)

Model‐Based Approach to Predict Adherence to Protocol During Antiobesity Trials
por: Sharma, Vishnu D., et al.
Publicado: (2017)

Population pharmacokinetics, enzyme occupancy, and 24S‐hydroxycholesterol modeling of soticlestat, a novel cholesterol 24‐hydroxylase inhibitor, in healthy adults
por: Yin, Wei, et al.
Publicado: (2023)

Advancing drug safety science by integrating molecular knowledge with post‐marketing adverse event reports
por: Soldatos, Theodoros G., et al.
Publicado: (2022)

Prediction of Nephropathy in Type 2 Diabetes: An Analysis of the ACCORD Trial Applying Machine Learning Techniques
por: Rodriguez‐Romero, Violeta, et al.
Publicado: (2019)

In Silico Profiling of Clinical Phenotypes for Human Targets Using Adverse Event Data
por: Soldatos, Theodoros G., et al.
Publicado: (2018)

Radioimmunotherapy in Non-Hodgkin’s Lymphoma: Retrospective Adverse Event Profiling of Zevalin and Bexxar
por: Sachpekidis, Christos, et al.
Publicado: (2019)

Adverse Event Circumstances and the Case of Drug Interactions
por: Soldatos, Theodoros G., et al.
Publicado: (2019)

Target Adverse Event Profiles for Predictive Safety in the Postmarket Setting
por: Schotland, Peter, et al.
Publicado: (2020)

Retrospective Toxicological Profiling of Radium-223 Dichloride for the Treatment of Bone Metastases in Prostate Cancer Using Adverse Event Data
por: Soldatos, Theodoros G., et al.
Publicado: (2019)

Association Between Serotonin Syndrome and Second‐Generation Antipsychotics via Pharmacological Target‐Adverse Event Analysis
por: Racz, Rebecca, et al.
Publicado: (2018)

Retrospective Side Effect Profiling of the Metastatic Melanoma Combination Therapy Ipilimumab-Nivolumab Using Adverse Event Data
por: Soldatos, Theodoros G., et al.
Publicado: (2018)

Public Adverse Event Data Insights into the Safety of Pembrolizumab in Melanoma Patients
por: Schaefer, Anne, et al.
Publicado: (2020)

No relevant cardiac, pharmacokinetic or safety interactions between roflumilast and inhaled formoterol in healthy subjects: an open-label, randomised, actively controlled study
por: de Mey, Christian, et al.
Publicado: (2011)

Quantitative Systems Pharmacology Model-Based Predictions of Clinical Endpoints to Optimize Warfarin and Rivaroxaban Anti-Thrombosis Therapy
por: Hartmann, Sonja, et al.
Publicado: (2020)

Pharmacokinetic and Pharmacodynamic Modelling to Characterize the Tolerability of Alternative Up-Titration Regimens of Roflumilast in Patients with Chronic Obstructive Pulmonary Disease
por: Facius, Axel, et al.
Publicado: (2018)

Reverse translation of adverse event reports paves the way for de-risking preclinical off-targets
por: Maciejewski, Mateusz, et al.
Publicado: (2017)

Constant-load exercise decreases the serum concentration of myeloperoxidase in healthy smokers and smokers with COPD
por: Holz, Olaf, et al.
Publicado: (2015)

Population Pharmacokinetic Meta-Analysis to Bridge Ferumoxytol Plasma Pharmacokinetics Across Populations
por: Plock, Nele, et al.
Publicado: (2014)

Pharmacokinetics and pharmacodynamics of the cytolytic anti‐CD38 human monoclonal antibody TAK‐079 in monkey – model assisted preparation for the first in human trial
por: Roepcke, Stefan, et al.
Publicado: (2018)

What Can Be Learned From Crowdsourced Population Asparagus Urinary Odor Kinetics?
por: Facius, Axel, et al.
Publicado: (2019)

Understanding adverse events of immunotherapy: A mechanistic perspective
por: Burke, Kelly P., et al.
Publicado: (2020)

A Population Pharmacokinetic Model of Vonoprazan: Evaluating the Effects of Race, Disease Status, and Other Covariates on Exposure
por: Scarpignato, Carmelo, et al.
Publicado: (2022)

Examining Socioeconomic and Computational Aspects of Vaccine Pharmacovigilance
por: Soldatou, Vasiliki, et al.
Publicado: (2019)

Sobol Sensitivity Analysis: A Tool to Guide the Development and Evaluation of Systems Pharmacology Models
por: Zhang, X‐Y, et al.
Publicado: (2015)

Reversibility of Central Nervous System Adverse Events in Course of Art
por: Taramasso, Lucia, et al.
Publicado: (2022)

Adverse Events of Antiepileptic Drugs Using Indonesian Version of Liverpool Adverse Events Profile
por: Budikayanti, Astri, et al.
Publicado: (2018)

Precision Oncology—The Quest for Evidence
por: Soldatos, Theodoros G., et al.
Publicado: (2019)

Ribosome profiling enhances understanding of mycobacterial translation
por: Sawyer, Elizabeth B., et al.
Publicado: (2022)

Evaluation of the Pharmacokinetics and Safety of a Single Oral Dose of Fasiglifam in Subjects with Mild or Moderate Hepatic Impairment
por: Marcinak, John, et al.
Publicado: (2018)

Understanding patterns of adverse events after surgery and their impact on recovery
por: Nash, Rachel L, et al.
Publicado: (2015)

Understanding How to Prevent and Treat Adverse Events of Fillers and Neuromodulators
por: Ablon, Glynis
Publicado: (2016)

Adverse event profiles of microscopic colitis in the Japanese Adverse Drug Event Report (JADER) database
por: Yamashiro, Kaito, et al.
Publicado: (2022)

Association of Oral Anticoagulants and Verapamil or Diltiazem With Adverse Bleeding Events in Patients With Nonvalvular Atrial Fibrillation and Normal Kidney Function
por: Pham, Phuong, et al.
Publicado: (2020)

Quantitative Systems Pharmacology Model to Predict the Effects of Commonly Used Anticoagulants on the Human Coagulation Network
por: Hartmann, S, et al.
Publicado: (2016)

Reverse Translation in Tuberculosis: Neutrophils Provide Clues for Understanding Development of Active Disease
por: Dorhoi, Anca, et al.
Publicado: (2014)

Just Culture for Medical Students: Understanding Response to Providers in Adverse Events
por: Shah, Brijen J., et al.
Publicado: (2021)

Understanding clinician perspectives on antibiotic associated adverse events to inform feedback
por: Cherian, Jerald, et al.
Publicado: (2023)

Comparison of the adverse event profiles of conventional and liposomal formulations of doxorubicin using the FDA adverse event reporting system
por: Fukuda, Akiho, et al.
Publicado: (2017)

MINDS: A Translator to Embed Mathematical Expressions Inside SPARQL Queries
por: Graux, Damien, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_qcsm1jl5ne66r5kam1vjl6o7ih