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Single‐dose of LC51‐0255, a selective S1P(1) receptor modulator, showed dose‐dependent and reversible reduction of absolute lymphocyte count in humans
Reducing the peripheral absolute lymphocyte count (ALC) is a promising therapeutic approach in treating autoimmune diseases. LC51‐0255 is a sphingosine‐1‐phosphate 1 receptor modulator, which is known to decrease the peripheral ALC. We aimed to assess the pharmacokinetics (PKs), pharmacodynamics (PD...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010277/ https://www.ncbi.nlm.nih.gov/pubmed/35045208 http://dx.doi.org/10.1111/cts.13227 |