Single‐dose of LC51‐0255, a selective S1P(1) receptor modulator, showed dose‐dependent and reversible reduction of absolute lymphocyte count in humans

Reducing the peripheral absolute lymphocyte count (ALC) is a promising therapeutic approach in treating autoimmune diseases. LC51‐0255 is a sphingosine‐1‐phosphate 1 receptor modulator, which is known to decrease the peripheral ALC. We aimed to assess the pharmacokinetics (PKs), pharmacodynamics (PD...

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Detalles Bibliográficos
Autores principales: Won Lee, Sang, Hwang, Inyoung, Oh, Jaeseong, Lee, SeungHwan, Jang, In‐Jin, Yu, Kyung‐Sang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010277/
https://www.ncbi.nlm.nih.gov/pubmed/35045208
http://dx.doi.org/10.1111/cts.13227

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010277/
https://www.ncbi.nlm.nih.gov/pubmed/35045208
http://dx.doi.org/10.1111/cts.13227

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