PARP inhibition impedes the maturation of nascent DNA strands during DNA replication

Poly(ADP-ribose) polymerase 1 (PARP1) is implicated in the detection and processing of unligated Okazaki fragments and other DNA replication intermediates, highlighting such structures as potential sources of genome breakage induced by PARP inhibition. Here, we show that PARP1 activity is greatly el...

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Detalles Bibliográficos
Autores principales: Vaitsiankova, Alina, Burdova, Kamila, Sobol, Margarita, Gautam, Amit, Benada, Oldrich, Hanzlikova, Hana, Caldecott, Keith W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010290/
https://www.ncbi.nlm.nih.gov/pubmed/35332322
http://dx.doi.org/10.1038/s41594-022-00747-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010290/
https://www.ncbi.nlm.nih.gov/pubmed/35332322
http://dx.doi.org/10.1038/s41594-022-00747-1

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