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Immune disease variants modulate gene expression in regulatory CD4(+) T cells

Identifying cellular functions dysregulated by disease-associated variants could implicate novel pathways for drug targeting or modulation in cell therapies. However, follow-up studies can be challenging if disease-relevant cell types are difficult to sample. Variants associated with immune diseases...

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Detalles Bibliográficos
Autores principales: Bossini-Castillo, Lara, Glinos, Dafni A., Kunowska, Natalia, Golda, Gosia, Lamikanra, Abigail A., Spitzer, Michaela, Soskic, Blagoje, Cano-Gamez, Eddie, Smyth, Deborah J., Cattermole, Claire, Alasoo, Kaur, Mann, Alice, Kundu, Kousik, Lorenc, Anna, Soranzo, Nicole, Dunham, Ian, Roberts, David J., Trynka, Gosia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010307/
https://www.ncbi.nlm.nih.gov/pubmed/35591976
http://dx.doi.org/10.1016/j.xgen.2022.100117