HLA autoimmune risk alleles restrict the hypervariable region of T cell receptors

Polymorphisms in the human leukocyte antigen (HLA) genes strongly influence autoimmune disease risk. HLA risk alleles may influence thymic selection to increase the frequency of T cell receptors (TCRs) reactive to autoantigens (central hypothesis). However, research in human autoimmunity has provide...

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Detalles Bibliográficos
Autores principales: Ishigaki, Kazuyoshi, Lagattuta, Kaitlyn, Luo, Yang, James, Eddie, Buckner, Jane H., Raychaudhuri, Soumya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010379/
https://www.ncbi.nlm.nih.gov/pubmed/35332318
http://dx.doi.org/10.1038/s41588-022-01032-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010379/
https://www.ncbi.nlm.nih.gov/pubmed/35332318
http://dx.doi.org/10.1038/s41588-022-01032-z

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