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Hidden information on protein function in censuses of proteome foldedness

Methods that assay protein foldedness with proteomics have generated censuses of apparent protein folding stabilities in biological milieu. However, different censuses poorly correlate with each other. Here, we show that the reason for this is that methods targeting foldedness through monitoring ami...

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Detalles Bibliográficos
Autores principales: Cox, Dezerae, Ang, Ching-Seng, Nillegoda, Nadinath B., Reid, Gavin E., Hatters, Danny M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010426/
https://www.ncbi.nlm.nih.gov/pubmed/35422070
http://dx.doi.org/10.1038/s41467-022-29661-2