A Foxo1-Klf2-S1pr1-Gnai1-Rac1 signaling axis is a critical mediator of Ostm1 regulatory network in T lymphopoiesis

Ostm1 mutations cause the severe form of osteopetrosis with bone marrow deficiency in humans and mice, yet a role in T cell ontogeny remains to be determined. Herein, we show that thymi of the Ostm1-null mice (gl/gl) from P8-to-P15 become markedly hypocellular with disturbed architecture. Analysis o...

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Detalles Bibliográficos
Autores principales: Mutabaruka, Marie S., Pata, Monica, Vacher, Jean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010627/
https://www.ncbi.nlm.nih.gov/pubmed/35434560
http://dx.doi.org/10.1016/j.isci.2022.104160

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010627/
https://www.ncbi.nlm.nih.gov/pubmed/35434560
http://dx.doi.org/10.1016/j.isci.2022.104160

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