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Locus coeruleus activation during environmental novelty gates cocaine-induced long-term hyperactivity of dopamine neurons

A key feature of the brain is the ability to handle novelty. Anything that is new will stimulate curiosity and trigger exploration. Novelty preference has been proposed to predict increased sensitivity to cocaine. Different brain circuits are activated by novelty, but three specific brain regions ar...

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Detalles Bibliográficos
Autores principales: Fois, Giulia R., Bosque-Cordero, Karl Y., Vazquez-Torres, Rafael, Miliano, Cristina, Nogues, Xavier, Jimenez-Rivera, Carlos A., Caille, Stéphanie, Georges, François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010629/
https://www.ncbi.nlm.nih.gov/pubmed/35434548
http://dx.doi.org/10.1016/j.isci.2022.104154