Sensor dimer disruption as a new mode of action to block the IRE1-mediated unfolded protein response

The unfolded protein response (UPR) is activated to cope with an accumulation of improperly folded proteins in the Endoplasmic reticulum (ER). The Inositol requiring enzyme 1α (IRE1α) is the most evolutionary conserved transducer of the UPR. Activated IRE1 forms ‘back-to-back’-dimers that enables th...

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Detalles Bibliográficos
Autores principales: Amarasinghe, Kosala N., Pelizzari-Raymundo, Diana, Carlesso, Antonio, Chevet, Eric, Eriksson, Leif A., Jalil Mahdizadeh, Sayyed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010685/
https://www.ncbi.nlm.nih.gov/pubmed/35465159
http://dx.doi.org/10.1016/j.csbj.2022.03.029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010685/
https://www.ncbi.nlm.nih.gov/pubmed/35465159
http://dx.doi.org/10.1016/j.csbj.2022.03.029

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