Prion protein with a mutant N-terminal octarepeat region undergoes cobalamin-dependent assembly into high–molecular weight complexes

The cellular prion protein (PrP(C)) has a C-terminal globular domain and a disordered N-terminal region encompassing five octarepeats (ORs). Encounters between Cu(II) ions and four OR sites produce interchangeable binding geometries; however, the significance of Cu(II) binding to ORs in different co...

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Detalles Bibliográficos
Autores principales: Daude, Nathalie, Lau, Agnes, Vanni, Ilaria, Kang, Sang-Gyun, Castle, Andrew R., Wohlgemuth, Serene, Dorosh, Lyudmyla, Wille, Holger, Stepanova, Maria, Westaway, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010764/
https://www.ncbi.nlm.nih.gov/pubmed/35271850
http://dx.doi.org/10.1016/j.jbc.2022.101770

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010764/
https://www.ncbi.nlm.nih.gov/pubmed/35271850
http://dx.doi.org/10.1016/j.jbc.2022.101770

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