An unexpected role for PD-L1 in front–rear polarization and directional migration

Programmed cell death-ligand 1 (PD-L1)–mediated T cell inhibition through PD-1 is a key checkpoint frequently exploited by tumors to evade immunity. In this issue, Wang et al. (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202108083) reveal an unexpected role for PD-L1 in promoting tumor cell fron...

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Detalles Bibliográficos
Autores principales: Sánchez-Álvarez, Miguel, del Pozo, Miguel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9011200/
https://www.ncbi.nlm.nih.gov/pubmed/35416931
http://dx.doi.org/10.1083/jcb.202203137
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author Sánchez-Álvarez, Miguel
del Pozo, Miguel A.
author_facet Sánchez-Álvarez, Miguel
del Pozo, Miguel A.
author_sort Sánchez-Álvarez, Miguel
collection PubMed
description Programmed cell death-ligand 1 (PD-L1)–mediated T cell inhibition through PD-1 is a key checkpoint frequently exploited by tumors to evade immunity. In this issue, Wang et al. (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202108083) reveal an unexpected role for PD-L1 in promoting tumor cell front–rear polarity and directionally persistent cell migration, independently of PD-1.
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spelling pubmed-90112002022-11-02 An unexpected role for PD-L1 in front–rear polarization and directional migration Sánchez-Álvarez, Miguel del Pozo, Miguel A. J Cell Biol Spotlight Programmed cell death-ligand 1 (PD-L1)–mediated T cell inhibition through PD-1 is a key checkpoint frequently exploited by tumors to evade immunity. In this issue, Wang et al. (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202108083) reveal an unexpected role for PD-L1 in promoting tumor cell front–rear polarity and directionally persistent cell migration, independently of PD-1. Rockefeller University Press 2022-04-13 /pmc/articles/PMC9011200/ /pubmed/35416931 http://dx.doi.org/10.1083/jcb.202203137 Text en © 2022 Sánchez-Álvarez and del Pozo https://creativecommons.org/licenses/by-nc-sa/4.0/http://www.rupress.org/terms/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Spotlight
Sánchez-Álvarez, Miguel
del Pozo, Miguel A.
An unexpected role for PD-L1 in front–rear polarization and directional migration
title An unexpected role for PD-L1 in front–rear polarization and directional migration
title_full An unexpected role for PD-L1 in front–rear polarization and directional migration
title_fullStr An unexpected role for PD-L1 in front–rear polarization and directional migration
title_full_unstemmed An unexpected role for PD-L1 in front–rear polarization and directional migration
title_short An unexpected role for PD-L1 in front–rear polarization and directional migration
title_sort unexpected role for pd-l1 in front–rear polarization and directional migration
topic Spotlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9011200/
https://www.ncbi.nlm.nih.gov/pubmed/35416931
http://dx.doi.org/10.1083/jcb.202203137
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