Endoplasmic reticulum stress downregulates PGC-1α in skeletal muscle through ATF4 and an mTOR-mediated reduction of CRTC2

BACKGROUND: Peroxisome proliferator-activated receptor γ (PPARγ) coactivator 1α (PGC-1α) downregulation in skeletal muscle contributes to insulin resistance and type 2 diabetes mellitus. Here, we examined the effects of endoplasmic reticulum (ER) stress on PGC-1α levels in muscle and the potential m...

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Detalles Bibliográficos
Autores principales: Montori-Grau, Marta, Aguilar-Recarte, David, Zarei, Mohammad, Pizarro-Delgado, Javier, Palomer, Xavier, Vázquez-Carrera, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012021/
https://www.ncbi.nlm.nih.gov/pubmed/35428325
http://dx.doi.org/10.1186/s12964-022-00865-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012021/
https://www.ncbi.nlm.nih.gov/pubmed/35428325
http://dx.doi.org/10.1186/s12964-022-00865-9

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