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Endoplasmic reticulum stress downregulates PGC-1α in skeletal muscle through ATF4 and an mTOR-mediated reduction of CRTC2
BACKGROUND: Peroxisome proliferator-activated receptor γ (PPARγ) coactivator 1α (PGC-1α) downregulation in skeletal muscle contributes to insulin resistance and type 2 diabetes mellitus. Here, we examined the effects of endoplasmic reticulum (ER) stress on PGC-1α levels in muscle and the potential m...
Autores principales: | Montori-Grau, Marta, Aguilar-Recarte, David, Zarei, Mohammad, Pizarro-Delgado, Javier, Palomer, Xavier, Vázquez-Carrera, Manuel |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012021/ https://www.ncbi.nlm.nih.gov/pubmed/35428325 http://dx.doi.org/10.1186/s12964-022-00865-9 |
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