Rapid Inhibitor Discovery by Exploiting Synthetic Lethality

[Image: see text] Synthetic lethality occurs when inactivation of two genes is lethal but inactivation of either single gene is not. This phenomenon provides an opportunity for efficient compound discovery. Using differential growth screens, one can identify biologically active compounds that select...

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Detalles Bibliográficos
Autores principales: Muscato, Jacob D., Morris, Heidi G., Mychack, Aaron, Rajagopal, Mithila, Baidin, Vadim, Hesser, Anthony R., Lee, Wonsik, İnecik, Kemal, Wilson, Laura J., Kraml, Christina M., Meredith, Timothy C., Walker, Suzanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012225/
https://www.ncbi.nlm.nih.gov/pubmed/35170959
http://dx.doi.org/10.1021/jacs.1c12697

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012225/
https://www.ncbi.nlm.nih.gov/pubmed/35170959
http://dx.doi.org/10.1021/jacs.1c12697

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