Histone methyltransferase WHSC1 loss dampens MHC-I antigen presentation pathway to impair IFN-γ–stimulated antitumor immunity

IFN-γ–stimulated MHC class I (MHC-I) antigen presentation underlies the core of antitumor immunity. However, sustained IFN-γ signaling also enhances the programmed death ligand 1 (PD-L1) checkpoint pathway to dampen antitumor immunity. It remains unclear how these opposing effects of IFN-γ are regul...

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Detalles Bibliográficos
Autores principales: Ren, Jiale, Li, Ni, Pei, Siyu, Lian, Yannan, Li, Li, Peng, Yuchong, Liu, Qiuli, Guo, Jiacheng, Wang, Xuege, Han, Ying, Zhang, Guoying, Wang, Hanling, Li, Yaqi, Jiang, Jun, Li, Qintong, Tan, Minjia, Peng, Junjie, Hu, Guohong, Xiao, Yichuan, Li, Xiong, Lin, Moubin, Qin, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012282/
https://www.ncbi.nlm.nih.gov/pubmed/35230972
http://dx.doi.org/10.1172/JCI153167

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012282/
https://www.ncbi.nlm.nih.gov/pubmed/35230972
http://dx.doi.org/10.1172/JCI153167

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