Combined noncanonical NF-κB agonism and targeted BET bromodomain inhibition reverse HIV latency ex vivo

Latency reversal strategies for HIV cure using inhibitor of apoptosis protein (IAP) antagonists (IAPi) induce unprecedented levels of latent reservoir expression without immunotoxicity during suppressive antiretroviral therapy (ART). However, full targeting of the reservoir may require combinatorial...

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Detalles Bibliográficos
Autores principales: Falcinelli, Shane D., Peterson, Jackson J., Turner, Anne-Marie W., Irlbeck, David, Read, Jenna, Raines, Samuel L.M., James, Katherine S., Sutton, Cameron, Sanchez, Anthony, Emery, Ann, Sampey, Gavin, Ferris, Robert, Allard, Brigitte, Ghofrani, Simon, Kirchherr, Jennifer L., Baker, Caroline, Kuruc, JoAnn D., Gay, Cynthia L., James, Lindsey I., Wu, Guoxin, Zuck, Paul, Rioja, Inmaculada, Furze, Rebecca C., Prinjha, Rab K., Howell, Bonnie J., Swanstrom, Ronald, Browne, Edward P., Strahl, Brian D., Dunham, Richard M., Archin, Nancie M., Margolis, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012286/
https://www.ncbi.nlm.nih.gov/pubmed/35426377
http://dx.doi.org/10.1172/JCI157281

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012286/
https://www.ncbi.nlm.nih.gov/pubmed/35426377
http://dx.doi.org/10.1172/JCI157281

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