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SMAD4 TGF-β–independent function preconditions naive CD8(+) T cells to prevent severe chronic intestinal inflammation
SMAD4, a mediator of TGF-β signaling, plays an important role in T cells to prevent inflammatory bowel disease (IBD). However, the precise mechanisms underlying this control remain elusive. Using both genetic and epigenetic approaches, we revealed an unexpected mechanism by which SMAD4 prevents naiv...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Clinical Investigation
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012287/ https://www.ncbi.nlm.nih.gov/pubmed/35426367 http://dx.doi.org/10.1172/JCI151020 |