SMAD4 TGF-β–independent function preconditions naive CD8(+) T cells to prevent severe chronic intestinal inflammation

SMAD4, a mediator of TGF-β signaling, plays an important role in T cells to prevent inflammatory bowel disease (IBD). However, the precise mechanisms underlying this control remain elusive. Using both genetic and epigenetic approaches, we revealed an unexpected mechanism by which SMAD4 prevents naiv...

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Detalles Bibliográficos
Autores principales: Igalouzene, Ramdane, Hernandez-Vargas, Hector, Benech, Nicolas, Guyennon, Alexandre, Bauché, David, Barrachina, Célia, Dubois, Emeric, Marie, Julien C., Soudja, Saïdi M’Homa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012287/
https://www.ncbi.nlm.nih.gov/pubmed/35426367
http://dx.doi.org/10.1172/JCI151020

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