Age-associated callus senescent cells produce TGF-β1 that inhibits fracture healing in aged mice

Cellular senescence plays an important role in human diseases, including osteoporosis and osteoarthritis. Senescent cells (SCs) produce the senescence-associated secretory phenotype to affect the function of neighboring cells and SCs themselves. Delayed fracture healing is common in the elderly and...

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Detalles Bibliográficos
Autores principales: Liu, Jiatong, Zhang, Jun, Lin, Xi, Boyce, Brendan F., Zhang, Hengwei, Xing, Lianping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012290/
https://www.ncbi.nlm.nih.gov/pubmed/35426372
http://dx.doi.org/10.1172/JCI148073

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012290/
https://www.ncbi.nlm.nih.gov/pubmed/35426372
http://dx.doi.org/10.1172/JCI148073

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